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Impact of Schistosoma Mansoni Infection on the Gut Microbiome and Hepatitis B Vaccine Immune Response in Fishing Communities of Lake Victoria, Uganda.

dc.contributor.authorWang Y.
dc.contributor.authorWaters A. K.
dc.contributor.authorBasalirwa G.
dc.contributor.authorSsetaala A.
dc.contributor.authorMpendo J.
dc.contributor.authorNamuniina A.
dc.contributor.authorKeneema E.
dc.contributor.authorKiiza D.
dc.contributor.authorKyosiimire-Lugemwa J.
dc.contributor.authorMayanja Y.
dc.contributor.authorOkech B.
dc.contributor.authorKiwuwa-Muyingo S.
dc.date.accessioned2025-07-24T07:23:19Z
dc.date.available2025-07-24T07:23:19Z
dc.date.issued2025
dc.identifier.urihttps://doi.org/10.3390/vaccines13040375
dc.identifier.urihttp://knowhub.aphrc.org/handle/123456789/2401
dc.description.abstractThis study examines the impact of Schistosoma mansoni infection on the gut microbiome and the immune response to the hepatitis B vaccine among Ugandan fishing communities. Participants were tested for S. mansoni and treated if infected, then received hepatitis B vaccination at baseline, 1 month, and 6 months. Stool samples were analyzed using 16S rRNA sequencing. Findings suggest that infection and increased microbiome diversity at baseline are associated with enhanced vaccine response, whereas older age is linked to weaker responses. This underscores the importance of infection control and microbiome optimization in vaccine programs for endemic areas.
dc.publisherMDPI
dc.subjectInfectious Disease II Gut Microbiome II Vaccine Immunogenicity II Schistosoma mansoni II Hepatitis B Vaccine II Public Health II LT?LMIC Health
dc.titleImpact of Schistosoma Mansoni Infection on the Gut Microbiome and Hepatitis B Vaccine Immune Response in Fishing Communities of Lake Victoria, Uganda.


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